The Significance of Insulin Resistance in Nondiabetic Breast Cancer Patients

Background: The relationship between insulin resistance (IR) and prognostic factors in breast cancer (BC) premenopausal (pre-M) postmenopausal (post-M) women is still controversial. We evaluated the potential association hemoglobin A1c (HbA1c), fasting blood glucose (FBG), levels (FILs), homeostasis model assessment index (HOMA), of BC nondiabetic patients with pre-M post-M tumors. Methods: compared 80 tumors to 60 normal mammography as a control. Results: Age, body mass (BMI), FBG, HbA1c did not differ groups. FIL (P < 0.001) HOMA-IR group were significantly higher than control group. group, for both pre- patients. values found be stage IV other stages BC. are highly specific sensitive parameters their ability diagnose Conclusions: associated risk When was according menopause, no difference observed; only disease significant. IR may function biomarkers therapeutic targets human cancers. J Endocrinol Metab. 2021;11(2):42-48 doi: https://doi.org/10.14740/jem729